منابع مشابه
The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases
Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...
متن کاملLinking immunity and hematopoiesis by bone marrow T cell activity.
Two different levels of control for bone marrow hematopoiesis are believed to exist. On the one hand, normal blood cell distribution is believed to be maintained in healthy subjects by an "innate" hematopoietic activity, i.e., a basal intrinsic bone marrow activity. On the other hand, an "adaptive" hematopoietic state develops in response to stress-induced stimulation. This adaptive hematopoies...
متن کاملCREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.
Populations of circulating immune cells are maintained in equilibrium through signals that enhance the retention or egress of hematopoietic stem cells (HSCs) from bone marrow (BM). Prostaglandin E2 (PGE2) stimulates HSC renewal and engraftment through, for example, induction of the cAMP pathway. Triggering of PGE2 receptors increases HSC survival in part via the PKA-mediated induction of the cA...
متن کاملHEMATOPOIESIS Hematopoiesis and stem cell renewal in long-term bone marrow cultures containing catalase
Culturing mouse bone marrow in the presence of catalase dramatically alters hematopoiesis. Granulocyte output is initially increased 4to 5-fold. This increase is transient and granulocyte production declines as immature (Sca-1 /LIN ) cells accumulate. One third of these immature cells have a phenotype (Sca-1 /c-Kit ) characteristic of hematopoietic stem cells. At 2 to 3 weeks there are greater ...
متن کاملFADD deficiency impairs early hematopoiesis in the bone marrow.
Signal transduction mediated by Fas-associated death domain protein (FADD) represents a paradigm of coregulation of apoptosis and cellular proliferation. During apoptotic signaling induced by death receptors including Fas, FADD is required for the recruitment and activation of caspase 8. In addition, a death receptor-independent function of FADD is essential for embryogenesis. In previous studi...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2018
ISSN: 1664-2392
DOI: 10.3389/fendo.2018.00694